Bioinformatics

Biography

Matteo Lo Monte completed his PhD in Medicinal Chemistry with a project entitled, “In silico screening of taste receptors: An integrate modeling approach” in 2015, at the “Universita’degliStudi di Milano”, under the supervision of Prof. Giulio Vistoli and in collaboration with Dompé Farmaceutici SpA, under Dr. Andrea Beccari. During this period, he mainly worked on the TRP receptors family, predicting their 3-D structure by homology modeling techniques and studying their interaction capacities as well as their activation mechanisms by Molecular Docking and Molecular Dynamic simulations; so generated models were conveniently utilized in virtual screening campaigns that successfully led to the identification of new hits. He moved to the Institute of Protein Biochemistry at the National Research Council in Naples in 2015 as Postdoctoral Fellow in the research group of Dr. Alberto Luini. He computationally supported several ongoing projects of Molecular Biology through molecular modeling and structural analyses studies of diverse enzymes like β4Galt5, SHIP1 and AGPAT4, as well as investigating the post-translational modifications, ADP-ribosylation in particular, developing predictive algorithms.

Abstract

Abstract : ADPredict: ADP-ribosylation sites prediction based on physicochemical and structure descriptors