Scientific Program

Conference Series LLC Ltd invites all the participants across the globe to attend .

Submit your Abstract
or e-mail to

Day :

 International Conference Keynote Speaker Amr I M Hawal photo
Biography:

Amr Ismael M Hawal is a Pediatrician and Neonatologist whose experience in the field spans 20 years, backed by a higher education degree from Ain Shams University in Egypt. He is pioneering an open and contextual evaluation model based on constructive responses, which has led in the creation of new methods to improve Pediatric Healthcare, Neonatology and Pediatric Nutrition. He has established this model following his years of experiences in medical practice, research and evaluation, teaching and administration in hospitals and medical universities in the region including Egypt, Saudi Arabia and the UAE. He has published several studies in reputable international journals in Neonatology and Pediatric Nutrition. He has also presented his findings in prestigious international conferences and symposia.

 

Abstract:

Statement of the Problem: It is a clinical case presentation of a male preterm infant newborn (+31 weeks), who was delivered in our hospital and transferred to our NICU because of prematurity, VLBW and need to respiratory support. Baby shortly underwent necrotizing enterocolitis (NEC) on 5th day of life shortly after start of expressed milk feeding. This was early detected by use of Near Infrared Abdominal Spectroscopy (NIRS). Baby was deteriorated clinically in a couple of hours and underwent intestinal perforation with peritonitis.

Methodology: Abdominal exploration surgery with intestinal resection and end to end anastomosis was done urgently. Baby improved gradually and early feedings was started and gradually increased up to full feedings with use of human fortified milk (HMF) and probiotics, prebiotics.

Findings: The study stated the evidence-based feeding strategy guidelines for necrotizing enterocolitis (NEC) among very low birth weight infants and role of trophic feedings, probiotics, prebiotics and micronutrients in prophylaxis, prevention and management of NEC. Prematurity is the single greatest risk factor for NEC and avoidance of premature birth is the best way to prevent NEC. The role of feeding in the pathogenesis of NEC is uncertain but it seems prudent to use breast milk (when available) and advance feedings slowly and cautiously. NEC is one of the leading causes of mortality and the most common reason for emergent GI surgery in newborns. NEC remains a major unsolved medical challenge for which no specific therapy exists and its pathogenesis remains controversial.

Conclusion: A better understanding of the pathophysiology will offer new and innovative therapeutic approaches and future studies should be focused on the roles of the epithelial barrier, innate immunity and microbiota in this disorder. Bioinformatics modeling is a new emerging strategy aimed at understanding the dynamics of various inflammatory markers and their application in early diagnosis and treatment.

 

 International Conference Keynote Speaker Julie Bouckaert photo
Biography:

Julie Bouckaert is associated with Université de Lille, France. She has published several papers in reputed journals. She is committed to highest standards of excellence and is proved through her authorship of many books. Her research interests include Systems Biology, Molecular Biology and Microbiology.

Abstract:

Shear force exerted on uropathogenic Escherichia coli adhering to surfaces makes type-1 fimbriae stretch out like springs to catch on to mannosidic receptors. This mechanism is initiated by a disruption of the quaternary interactions between the lectin and the pilin of the two-domain FimH adhesin and transduces allosterically to the mannose-binding pocket of FimH to increase its affinity. Shear stress protects Escherichia coli cells adhering to surfaces via catch bonds from detachment by soluble inhibitors present in urine. Mannose-specific adhesion of 14 E. coli pathovars was measured under flow, using surface plasmon resonance detection on functionalized graphene-coated gold interfaces. Increasing the shear had important differential consequences on bacterial adhesion. Adherent-invasive E. coli, isolated from the feces and biopsies of Crohn’s disease patients, consistently changed their adhesion behavior less under shear and displayed lower SPR signals, compared to E. coli opportunistically infecting the urinary tract, intestines or loci of knee and hip prostheses. We exemplified this further with the extreme behaviors of the reference strains UTI89 and LF82. Whereas their FimA major pilins have identical sequences, FimH of LF82 E. coli is marked by the Thr158Pro mutation. Positioned in the inter-domain region known to carry hot spots of mutations in E. coli pathotypes, residue 158 is indicated to play a structural role in the allosteric regulation of type-1 fimbriae-mediated bacterial adhesion. In a next stage, we plan to investigate structure-function relationships of FimH using several mannosylated protein receptors and antagonists immobilized on graphene or supplied in solution and interacting with E. coli strains under varying flow conditions. 

 International Conference Keynote Speaker Jia Guo photo
Biography:

Jia Guo is an Associate Professor at Xiangya School of Nursing Central South University. She has been working as the Principal Investigator of many international and domestic grants in diabetes management and prevention.

Abstract:

Diabetes self-management is the key to attain desired control goals. Youth with type 1 diabetes experience special self-management challenges and a great amount of stress. Little research has examined the perceived stress faced by Chinese youth with type 1 diabetes, or explored the psychosocial correlates of their self-management. The purpose of this study was to: a) to determine if self-efficacy mediates the relationship between perceived stress and diabetes self-management; and b) to explore whether perceived stress moderates the self-efficacy and diabetes self-management relationship. Methods: Using a cross-sectional study design, the youth with type 1 diabetes were recruited from a diabetes clinic from January 2016 to December 2016 in Central South of China. Data on demographic and clinical characteristics, perceived stress, self-efficacy, and diabetes self-management were collected. Descriptive analyses and regression analyses were generated by SPSS Version 22. Structural equation modeling was implemented with the MPlus program. Results: A total of 149 youth with a mean age of 13.9 years were investigated. There was no direct effect of perceived stress on diabetes self-management (p>0.05); however, self-efficacy mediated the relationship between perceived stress and diabetes self-management. Lower perceived stress was associated with better self-efficacy (r=-0.67; p<.01). The combination of high self-efficacy and low perceived stress shows better self-management than would be predicted from the main effects of self-efficacy and perceived stress alone. Conclusions: Decreasing perceived stress and improving self-efficacy are important strategies to achieve optimal diabetes self-management. Ways to improve youths' self-efficacy and ability to cope with stress should be the primary goal of diabetes education for Chinese youth with type 1 diabetes to improve diabetes self-management.

 

 International Conference Keynote Speaker Kamran Mirza photo
Biography:

Kamran Muhammad Mirza has completed his MBBS from the Aga Khan University in Karachi, Pakistan and PhD from University of Illinois in Chicago, IL. He was trained in Combined Anatomic and Clinical Pathology with Fellowships in Hematopathology, Thoracic Pathology and Medical Education at the University of Chicago. He is an Assistant Professor of Pathology and Medical Director of Molecular Pathology at Loyola University Chicago Stritch School of Medicine in Maywood, IL. He is the recipient of numerous pathologist-in-training awards, teacher-of-the year awards and honors such as induction into the Alpha Omega Alpha honor society and selection into American Society for Clinical Pathology's 40 Under Forty 2017.

 

Abstract:

Molecular diagnostics and personalized medicine is revolutionizing the way we approach medicine and treatment of disease. Hematopathology was one of the first of the pathology subspecialties to welcome molecular classification into its classification scheme when it introduced the WHO classification in 2001. Since then, the validity and importance of molecular data has increased million folds and continues to increase every day. As pathologists, we need to harness and embrace the power of molecular pathology in our daily practice and hematopathology has led the way. This lecture serves as a historical overview from the discovery of the t(9;22) in CML and the inclusion of the "AMLs with recurrent cytogenetic abnormalities" and how the classification scheme has evolved from WHO 2001, to 2008 and now to 2016. This lecture serve to update the audience on the changes in the WHO 2016 update to leukemia diagnosis in the WHO classification, discuss next generation sequencing and where its utility stands in the diagnosis of leukemia and the future of the field.

Keynote Forum

Paula Hodgson

The Chinese University of Hong Kong, Hong Kong

Keynote: Personalized medication advice using mobile apps
 International Conference Keynote Speaker Paula Hodgson photo
Biography:

HODGSON was one of the pioneers in promoting and supporting e-learning in Hong Kong. She has worked in higher education since 1997, serving in The Hong Kong Polytechnic University, University of Auckland, University of Hong Kong, City University of Hong Kong, Hong Kong Baptist University, and now Chinese University of Hong Kong (CUHK). Her research areas include technology-enriched teaching and learning, assessment in higher education, and massive open online courses. Concurrently, she is the co-principal investigator of the following joint-university Teaching and Learning Projects 2016–19 funded by the University Grants Committee:
(1) ‘Coding, Design, and Global Involvement: Engaging Students in Multi-domain Active Learning through the Creation of Mobile Apps and an Apps Resource Centre (ARC)’; (2) ‘Augmenting Physical Learning Spaces with Location-based Services Using iBeacon Technology for Innovative Learning and Teaching’; and (3) ‘Enhancing Learning Outcomes for Students through a Data-driven Review of the 4-year Curriculum in UGC-funded Programs’. She has been invited to present in ASEAN University Network on quality assurance and universities. She has made over 150 publications.

Abstract:

Patients in community are given medication aft er they have been treated in hospitals or local clinics. Although a licensed pharmacist will explain type of drugs and dosage when issuing drug, patients may follow them closely or miss out if they have not paid attention to. More oft en, they may not have time to discuss about the side eff ects with the pharmacist. Th erefore, it would be very useful to have a mobile application on health record, drug information, pharmacist information and medical appointment with medication information and health conditions of individuals. Currently, this is a mobile application that is under development in Hong Kong to provide an additional e-health support for patients or users who can get
useful health information, drug information or make a web-conferencing appointment with a pharmacist through the platform in Hong Kong: http://www.ampoule.org.hk/. It will take six to eight months to design and develop the mobile application. A pilot test will be conducted in Spring 2019. It is hoped that the application can off er an ongoing medication advice when a patient or user of the system need diff erent types of treatment or medical service providers. Moreover, a special feature is to connect family members
with the patient such that members will receive short message service (SMS) about medical appointment of the patient. As Hong Kong face the challenge of aging population, the mobile application can serve a better connection between family members and the pharmacy community.

 International Conference Keynote Speaker Narender singh photo
Biography:

Dr. Narender Singh received his Ph.D. at the University of Houston in 2007 in the field of Drug Discovery. He spent 2007-2009 as a postdoctoral fellow at UT-Houston and TPIMS-FL, and following that joined the HJF for the Advancement of Military Medicine in Maryland working in the field of military relevant problems such as infectious pathogens and muscle injury. In 2014, he moved to Huntsville and joined CFDRC as a Senior Research Scientist working in the field of modeling Organ-on-Chip devices, PBPK, computational nanotoxicology, drug design, and cheminformatics. He has published more than 14 articles with 500+ citations.
Presenting author

Abstract:

Pulmonary drug delivery via oral inhalation is increasingly used for both treatment of lung diseases and for delivering drugs to the systemic circulation. Efficacy and safety of orally inhaled drugs is dependent on deposition and absorption of drugs in targeted region. However, due to the complex pharmaceutical and physiological factors involved in drug transfer from the administration site to the target region, it is difficult to experimentally capture the detailed mechanistic insights of involved pulmonary drug delivery processes.
In the present study, we have developed a novel predictive multiscale computational tool to simulate delivery, deposition, dissolution, absorption, distribution, metabolism, excretion, and actions of inhaled drug products within an integral framework of computational fluid dynamics (CFD) and PBPK-PD models. The tools and models will be used in predicting the effects of inhalation devices, drug formulation, compound physiochemical characteristics, physiological settings, and various pathological factors on drug deposition and distribution. Ultimately, we aim to provide not only the detailed mechanistic insights into key aspects affecting efficacy and safety of inhaled drug products, but also to guide optimal designs of pulmonary drug delivery systems, inhaled formulations, to prescribe these therapies optimally.

Keynote Forum

Shamim Ahmad

Aligarh Muslim University, India

Keynote: Honey in medicine: Past, present and future
 International Conference Keynote Speaker Shamim Ahmad photo
Biography:

Shamim Ahmad is a Distinguished Professor of Microbiology and Officer In-Charge at Microbiology Section, Institute of Ophthalmology, Aligarh Muslim University, India since 1983. He has earned his PhD in 1982 and obtained his Postdoctoral training in various Departments of Microbiology at the universities in six countries. His research work mainly involved multi resistant eye pathogens including super bugs MRSAs and their alternative treatment with newer antibacterial and innovative natural products especially honey. He has published many papers, one book and three book chapters in international books. He is a member of the Editorial Team including Chief Editor of at least 68 international journals of world repute.

Abstract:

In view of the world wide prevalence and alarming increase in the antibiotic resistance among multi-resistant clinical bacteria and superbugs, a search for an effective alternate antibacterial natural agent like honey is urgently required. Honey in the past has occupied a prominent place in traditional medicines throughout world history. The Noble Holy Quran and many Prophetic narrations have also referred honey as a great healer of diseases. Honey was used to treat the infected wounds 2000 years before the bacteria were discovered. Ayurvedic and Unani Medicine have been using honey as a vital medicine for centuries. Presently, Branded Manuka Honey and many commercial products being possessing antimicrobial, anti-inflammatory and antioxidant medicinal properties have now flooded world market and shown to be highly effective for the treatment of many wound infections, burns, sore throat, psoriasis, gastrointestinal disorders, arthritis, eczema, dental carries, stomach aches, flu like symptoms and corneal ulcers. Recently, a large number of workers have explored honey’s miracles in ophthalmology, dentistry, surgery, plastic surgery, pediatrics, dermatology, gynecology and gastroenterology. A long term in vitro and in vivo researches on antibacterial and curative effects of honey even on Methicillin Resistant Staphylococcus aureus (MRSA) from eye patients in UK along with treatment trials in dry eye syndromes in human beings provides potential prospects and scope of honey as an alternate antibacterial option in various fields of medicine in future to fight with the most difficult resistant bacterial pathogens.

 International Conference Keynote Speaker Diana Anderson photo
Biography:

 

Diana Anderson (H index 54) holds the Established Chair in Biomedical Sciences at the University of Bradford. She obtained her first degree in the University of Wales and second degrees in the Faculty of Medicine, University of Manchester. She has 450+ peer-reviewed papers, 9 books, has successfully supervised 30 PhDs, is an Editorial Board Member of 10 international journals. She is Editor-in-Chief of a book series on Toxicology for the Royal Society of Chemistry. She gives key note addresses at various international meetings. She is a consultant for many international organisations, including WHO, EU, NATO, TWAS, UNIDO, OECD.

Abstract:

Spermatogonial stem cells (SSCs) are responsible for transmission of genetic information from males to their progeny. SSCs play pivotal roles in spermatogenesis and reproductive biology of gametes and treatment of infertility. Many chemicals have a negative impact on the SSCs, either directly, or indirectly through the somatic nursing cells. Eventually, these effects can inhibit fertility, and they may have negative consequences for the development of the offspring. Oxaliplatin is a platinum-organic drug with antineoplastic properties used for colorectal cancer and cytotoxicity due to platinum binding to DNA and the formation of intrastrand cross-links between neighbouring guanines. This study was to establish an oxidative stress model for antioxidant activity of some drugs investigated in SSCs in in vitro culture. The effects of oxaliplatin on SSCs were evaluated by standard cytotoxicity assays and the potential biochemical and molecular effects on the antioxidant system. Administration of oxaliplatin showed significant increases in DNA damage, p53 and bcl-2 gene expression levels concomitant with significant decreases in endogenous antioxidant enzymes SOD, CAT and GPx-mRNA gene expression. Glial cell line–derived neurotrophic factor (GDNF) is important for SSC self-renewal in vitro and in vivo, so we also assessed oxaliplatin on GDNF-mediated signalling in these cells and oxaliplatin significantly decreased GDNF-mRNA and associated protein. Oxaliplatin-induced DNA damage causes an increase in intracellular superoxide anions which are reduced by the exogenous antioxidant flavonoid, quercetin. This study highlights evidence that SCCs have antioxidant and antiapoptotic properties that could reverse oxaliplatin-induced testicular toxicity, in addition to their role in spermatogenesis.

 

Keynote Forum

René Hensel

INM – Leibniz Institute for New Materials, Germany

Keynote: Bio-inspired elastomeric adhesives for novel pick-and-place concepts
 International Conference Keynote Speaker René Hensel photo
Biography:

René Hensel studied Materials Science at the TU Dresden, Germany. He was a fellow of the DFG Research Training Group 1401/2 at the TU Dresden and did his
Doctorate at the Leibniz Institute of Polymer Research Dresden (IPF) and the Max Bergmann Center of Biomaterials Dresden (MBC). He was honored with the
International Bionic Award 2014 from VDI for his PhD thesis on free-standing polymer membranes for omniphobic surface coatings. Since 2014, he has been the
Deputy Head of the Program Division Functional Microstructures at Leibniz Institute for New Materials Saarbrücken, Germany.

Abstract:

Strong, but reversible adhesion to diverse counter surfaces has attracted the attention of several research groups worldwide.
Inspired from concepts found in biology, micropatterned dry adhesives were identifi ed as promising candidates, particularly
due to their potential for the development of novel pick-and-place concepts. Whereas, fundamental principles and design
guidelines of such adhesives to handle objects with smooth surfaces have already been reported in several reports; current
developments undergo rapid progress towards applications in non-ideal conditions. Here, we will discuss the impact of surface
roughness among other scenarios such as elevated operating temperatures and a reduced air pressure. As an example, surface
roughness substantially reduces contact area; however, we found that an appropriate design of the surface pattern can lead to
acceptable adhesion performances. By an intense interplay between experiment and theory, we studied a new composite design
that maintains the structural concept of contact splitting in combination with soft materials to overcome critical issues in
contact formation such as the strain energy penalty. Our developments demonstrate practical solutions for current limitations
and might pave the way for emerging applications of bio-inspired pick-and-place systems in the real world.

 International Conference Keynote Speaker Mahreen Ul Hassan photo
Biography:

Abstract:

 International Conference Keynote Speaker Raymond C Jagessar photo
Biography:

Raymond C. Jagessar obtained his BSc (Distinction) in Chemistry/Biology from the University of Guyana (1992) and his Ph.D. from the UK (1995). He held three Post-Doctoral Research Fellowships (PDF) at various universities overseas. He has also won several international awards, amongst them are Chartered Chemist, CChem and Fellow of the Royal Society of Chemistry, FRSC, UK, Research and traveling Grants etc. His research interests are broad, covering the spectrum of Pure and Applied Chemistry, Chemical Biology and Pharmaceutical Chemistry. He has published over eighty (80) research articles, five book chapters and presented at conferences: locally and internationally. He is currently Professor in Chemistry at the University of Guyana (South America).

 

Abstract:

There are several interesting reports on the electrical properties of meso-substituted porphyrins. Meso-substituted porphyrins electrical properties can be modulated through various meso-substituted patterns and the use of the type of metal in porphyrin metal complexation. This class of compounds has yielded interesting results in the nanopore arena or embodiment. Thus, their availability via high yielding synthesis is necessary. Hence, a route to porphyrins bearing trans-thiols is described in this lecture. The synthesis involves a thioacetyl containing aldehyde or a thioacetyl containing dipyrromethane in the presence of catalytic BF3.OEt2 followed by oxidation. Metal complexation and ammonium hydroxide induced acetyl removal to provide a route to these important molecular systems for future electronics experiments in which the thiols would serve as the adhesion points to gold probes

 International Conference Keynote Speaker BIA Separations photo
Biography:

Abstract:

Keynote Forum

Dr Arundeep Kaur

Maulana Azad Institute of Dental Sciences, New Delhi, India

Keynote: Principles of soft tissue grafting for strategic & predictable success
 International Conference Keynote Speaker  Dr Arundeep Kaur photo
Biography:

A graduate & post graduate from Punjab Govt. Dental College & hospital from Amritsar with distinctions in the subject of Periodontics & General Surgery & Sixteen Medals in different subjects, she has been working in the capacity of Head of Periodontics at Maulana Azad Institute of Dental Sciences for the last 30 years & has over 85 publications in indexed journals. The lives of many patients and students have been enriched as a result her innovative thinking, clinical expertise & knowledge.

 

Abstract:

The field of periodontal surgery dealing with the correction of anatomic, developmental or trauma and disease induced defects of gingiva, alveolar mucosa and bone is known as periodontal plastic surgery. It includes but is not limited to deepening of shallow vestibule, widening of attached gingiva, ridge augmentation, coverage of denuded roots, reconstruction of papillae and periodontal prosthetic corrections. These procedures maybe performed to accomplish any of the objectives such as correction of the width of attached gingiva oranaberrant frenum. Objectives such as esthetic surgical therapy and tissue engineering have widened the horizons of periodontal plastic surgery. Substantial ground breaking research around various surgical techniques and their modifications started after the 1920s. However, sophisticated and relatively newer techniques such as the pinhole technique, VISTA etc. have been published in the last decade. These modern methods have increased clinical efficiency and improved ergonomics.  The periodontist today has a vast array of procedures and materials to choose from. This paper presents the principles of soft tissue grafting for predictable success including the steps involved in clinical case selection, to aid the decision making process and collates all relevant techniques and contemporary surgical objectives so as to provide clinicians a holistic picture of all the surgical methods and techniques at their disposal.

 International Conference Keynote Speaker Renata Pasqualini photo
Biography:

Renata Pasqualini is the Professor of Medicine and Cancer Experimental Therapeutics, Associate Director for Translational Research and Chief of the Division of
Molecular Medicine at the University of New Mexico Comprehensive Cancer Center. She has received her PhD from the Ludwig Institute for Cancer Research and
did Postdoctoral training at Harvard Medical School and at the Burnham Institute in La Jolla, CA. In addition to her activities as the Principal Investigator and Head
of a large research laboratory, fi rst at the University of Texas MD Anderson Cancer Center and presently at the University of New Mexico Health Sciences Center,
she serves as a Board Member, Reviewer and Chair in multiple review panels for the National Institutes of Health, the Department of Defense, the Department
of Energy along with several other American, Asian and European Foundations that support basic and clinical research. She is a Referee for several top journals
featuring cutting edge research and technology and has published over 200 papers.

Abstract:

We have developed in vivo phage display, a functional peptide and antibody screening established in animal models and
later in patients, to isolate homing ligands and enable subsequent identifi cation of tissue-specifi c receptors. Systematic
implementation of this strategy advanced the construction of a comprehensive map of vascular markers in each organ, tissue
or disease. Indeed, our pioneering discoveries of tissue-specifi c and angiogenesis-related receptors (vascular "ZIP codes") may
lead to a new ligand-directed pharmacology. Over the last few years our eff orts have been focused on characterizing the
vascular diversity associated with individual cancer patients using antibody-based drug discovery in a precision medicine
context and optimizing targeted nanoparticles for drug delivery without off -target toxicity. Th ese new programs represent
fertile ground for discovery and drug development.

Keynote Forum

Falah Ali

University of Sussex, UK

Keynote: 5G The Next Frontier in Wireless Communications
 International Conference Keynote Speaker Falah Ali photo
Biography:

Falah Ali is currently a Reader in Digital Communications at the University of Sussex. He leads the Communications Research Group in the Department of Engineering and Design. He received his PhD from the University of Warwick, and his MSc and BSc from Cardiff University, in the UK. He also held a postdoctoral position at Lancaster University focused on advanced multiple access techniques for wireless communications. He published over 100 papers in reputable journals and conferences and has served as a chair and member of technical programme committees in several conferences. His research interests are in 5G wireless communications systems. He is a Fellow of IET, a Senior member of IEEE, and a Chartered Engineer.

Abstract:

5G is much more than just evolution of the mobile technology. It will empower new functionalities for people, society and enterprise. 5G is expected to provide fibre like data rate with massive system capacity, and ultra-reliable and extreme real-time communications. These are vital in the advancements of many new applications including the Internet-of-Things, driverless cars, virtual reality, tactile internet and more. In this talk, I will provide an overview of 5G vision and performance targets followed by some key enabling technologies and examples of the research work at the University of Sussex.

 International Conference Keynote Speaker Hans Von Holst photo
Biography:

Hans von Holst received his MD´s degree in 1976 and specialist in Neurosurgery 1982, Karolinska University Hospital. In 1985 he earned his PhD and Associate Professorship in Neurosurgery, Clinical Neuroscience, Karolinska Institutet and appointed as senior neurosurgeon 1988 - 2015. During 1991-1996 he was Chairman of the Dept of Neurosurgery and Division Manager of the Neuroclinics at Karolinska University Hospital, respectively. Between 1994-2014 he was appointed as Professor in Neuroengineering, KTH Royal Institute of Technology and visiting Professor at Karolinska Institutet 2006-2012, He has published over 150 original papers in reputed journals, reviews and books including editorial board member in several journals.

 

Abstract:

Increased intracellular water content defined as cytotoxic brain tissue edema is a serious secondary clinical complication to traumatic brain injury (TBI) and stroke and without knowledge to the etiology. Recently a hypothesis to the nervous tissue edema was presented suggesting that external dynamic and internal mechanical static impact forces caused protein unfolding resulting in an increased brain tissue water content and what happens with the metabolism in the long run. The hypothesis was confirmed by computer simulation tests. In this laboratory study we further evaluated the hypothesis by using the mature protein laminin LN521 upon the effects of both dynamic as well as static impact forces, respectively. The treated laminin solutions were then analyzed with denatured electrophoresis and Electron Microscopy showing aggregation and fragmentation of the laminin structures. The present laboratory results confirm earlier hypothesis and computer simulation suggesting for the first time that dynamic impact force in an accident and increased mechanical static force in stroke unfold mature proteins having the potential to increase the intracellular water content defined as cytotoxic brain tissue edema. The clinical condition resembles the phenomenon when elasmobranchs including white sharks prevent their cells from too high hydrostatic pressure in the deep sea. Thus, the present laboratory study results and knowledge from marine physics may be considered to improve the clinical treatment and outcome of TBI and stroke patients. This opens up new perspectives how vascular dementia in TBI and Stroke should be looked upon when it come sto clinical treatment.

 

 International Conference Keynote Speaker Denis Larrivee photo
Biography:

Dr. Denis Larrivee is a Visiting Scholar at the Mind and Brain Institute, University of Navarra Medical School and Loyola University Chicago and has held professorships at the Weill Cornell University Medical College, NYC, and Purdue University, Indiana. A former fellow at Yale University's Medical School he received the Association for Research in Vision and Ophthalmology's first place award for studies on photoreceptor degenerative and developmental mechanisms. He is the editor of a recently released text on Brain Computer Interfacing with InTech Publishing and an editorial board member of the journals Annals of Neurology and Neurological Sciences (USA) and EC Neurology (UK). An International Neuroethics Society Expert he is the author of more than 70 papers and book chapters in such varied journals/venues as Neurology and Neurological Sciences (USA), EC Neurology (UK), Journal of Neuroscience, Journal of Religion and Mental Health, and IEEE Explore. In 2018 he was a finalist in the international Joseph Ratzinger Expanded Reason award.

Abstract:

Writing in 2006, on the occasion of the 100th anniversary of Alloys Alzheimer's first description of Alzheimer's Dementia (AD), Dr K Jellinger of the Institute of Clinical Neurobiology, Vienna noted 'that despite considerable progress in the clinical diagnosis, neuroimaging, genetics, molecular biology, neuropathology, defining risk factors, and treatment, the etiology of the disease is still unknown and, therefore, a causal treatment of AD will not be available in the near future.' Similar absences mark studies of other notable cognitive diseases, like schizophrenia, suggesting that current models and experimental studies may be directed to non-etiological features of the diseases. Significantly, cognitive diseases display both mental and physical symptomatic signatures. Hence, new conceptions on what is being progressively impaired in these diseases are needed to underwrite therapeutic advances both for the restoration of mental as well as physical health. Such inferences are likely to come from studies on the brain's global regulation, since a key symptom of these diseases  is a pathological progression in the loss of self perception. Existing studies reveal, for example, that a fundamental brain network needed for the self construct, the default mode network (DMN), which is critical to monitoring the external environment, bodily states, and even emotions, is impaired in AD. Furthermore, functional MRI shows that activity in the posterior cingulate and right inferior temporal cortex and that in the bilateral inferior parietal cortex, are differentially affected, reflecting a weakening of causally influential relations amongst the DMN principal nuclei. Schizophrenia patients, on the other hand, display an inability to identify self initiated actions, which is likely due to a failure to link self representations to the body, that may originate in the DMN and premotor cortices. Therapeutic strategies that enhance the neural underpinning of self representations may therefore delay symptomatic progression in these diseases. Increasing evidence suggests that practices that enhance self integration, like contemplation, may assist in strengthening these features. This talk will discuss current research on the impact of these cognitive diseases on the neural representation of the self, and the potential use of contemplative practice in strengthening the self representation and delaying symptomatic onset.