Afsheen Mushtaque Shah
University of Sindh, Pakistan
Title: Hematological Abnormalities in patients with Active Pulmonary Tuberculosis
Biography
Biography: Afsheen Mushtaque Shah
Abstract
Mycobacterium Pulmonary Tuberculosis (PTB) is an enduring infectious disease of the world. Pakistan is a developed nation where the prevalence of pulmonary TB increases and graded as 5th mid of 22 TB elevated countries and is the second leading cause of death in the world. As a risk factor of PTB, tobacco smoking has increased substantially over the past three decades, especially in developing countries. Multidrug-resistant TB (MDR-TB) has become a significant public health problem. Abnormalities in hemoglobin, hematocrit levels and Erythrocyte Sedimentation Rate (ESR) are usually disturbed in infectious disease. The aim of this study was to determine the hematological changes in active pulmonary TB patients and compare with normal healthy control subjects. Total of 338 patients of both genders age ranged 20 to 60 years, with positive sign and symptoms of tuberculosis were selected from Institute of Chest Disease, kotri, Sindh, Pakistan, Liaquat University of Medical & Health Sciences, Jamshoro, Sindh, Pakistan, Liaquat University Hospital, Hyderabad, Sindh, Pakistan, & Rajputana Hospital, Hyderabad, Sindh, Pakistan. Blood was collected from each subject and sent to the research laboratory. Informed consent was taken prior to collection of sample. Our study was based on two groups. One was the Refamipicin sensitive PTB patients (RSPTB) and the other was Refampicin Resistant PTB patients (RRPTB) The mean ages of both gender of RSPTB and RRPTB patients were 36.7±14.1 and 34.0±13.9 years. The male and female patients of RSPTB were 94 and 70 while in RRPTB the male and females were 100 and 74. In RRPTB, the hematological parameters including RBC, PCV, MCH, MCHC, WBC N, L, M,E, PLT & ESR (4.2 ± 0.5), (32.6±5.1),(26.8±3.8), (31.0±1.4), (1.3±3.5),(82.4±9.2), (16.2±6.2), (11.6±5.5), (7.1±1.0), (3.4±1.4) & (63.3±31.1) were significantly higher and MCV (73.6±12.4) were significantly lower. While in RSPTB (3.7±0.7), (30.6±4.7), (23.1±4.0), (29.8±3.2), (1.2±4.2), (81.6±6.1), (16.98±7.5), (8.99±6.3), (5.1±1.8), (3.4±1.3), & (42.5±43.2) were significantly lower and MCV were (76.4±11.1), were significantly higher. As compare to control group all the biochemical parameters were statistically significant. It is conclude that hematological abnormities have a significant role in cure of patients suffering from active pulmonary tuberculosis.